Stop the proliferation of residual tumor cells.
Placed at the time of tumor resection, GammaTile® implantable collagen tiles deliver immediate, targeted radiation, from inside the tumor cavity, for advanced local control.1-8
Why GammaTile?Why
GammaTile?
More dose,
where you want it,
when you need it.9
GammaTile precisely delivers radiation directly to the resection cavity when the tumor burden is at its lowest, while minimizing exposure to healthy brain tissue.9
Bioresorbable,
conformable collagen tiledesigned for precise, safe and effective internal radiation therapy.10
conformable collagen tile
- Each tile has four cesium-131 (Cs-131) seeds, with a half-life of 9.7 days.11,12
- Seeds are offset 3mm from the surface of the tile to prevent very high dose radiation from coming in contact with adjacent brain tissue.11,12
- Fixed source strength (3.5 U/seed) at implant reduces dosimetric variability across patients and may simplify studying outcomes.11
Controlled dose
Uniform radiation-source spacing helps give predictable, therapeutic radiation dose for advanced tumor control.11
The GammaTile difference
immediate, targeted, controlled
radiation therapy
In a retrospective dosimetric review of treatment options for recurrent brain metastasis, GammaTile is shown to deliver precise radiation directly to the resection cavity (RC), with minimal exposure to surrounding brain tissue.9
Axial illustration demonstrating the differences in biologically effective dose (BED) distribution amongst the radiation modalities
Images courtesy of Miami Cancer Institute.
BED10Gy90% Median
Results9
- GammaTile delivers statistically significant higher BED at the RC than the other modalities (all p <0.05).
- GammaTile’s BED was significantly lower 5mm away from the RC as compared to CyberKnife® (p = 0.045) and proton therapy (p = 0.03).
- Dose metrics associated with radiation necrosis are significantly lower for GammaTile on pairwise comparisons (all p <0.05).
Brachytherapy reimagined
GammaTile’s innovative, tissue-sparing design addresses the challenges and limitations seen in traditional brain brachytherapy, such as the use of Iodine-125 and loose seed placement, particularly uneven dose distribution and exposure to healthy brain tissue.10
Faster
radiation delivery with shorter treatment duration.10
Increased
local control.1-8,10
Low rates
of radiation necrosis.1-8,10
Hear from
GammaTile
physicians
The GammaTile Commitment Pledge
for recurrent brain tumors
If a GammaTile treatment of a recurrent brain tumor is canceled because intraoperative pathology reveals only necrotic tissue, we will update the invoice to reflect a $0 charge.*