GammaTile

Brachytherapy
reimagined

GammaTile® is a bioresorbable collagen implant embedded with four cesium-131 (Cs-131) seeds that delivers therapeutic radiation dose to the tumor cavity, while limiting the dose to healthy brain tissue.1

FeatureGammaTile
(with Cs-131)2		Traditional
Brachytherapy
(with Iodine-125)2		Benefit of
GammaTile2
Half-life9.7 days 59.4 daysShorter treatment duration, faster radiation delivery
Radiation Dose DeliveryCompletes 88% in 30 days3Completes 88% in 184 days3Faster therapeutic effect
Reoperation Related to Radiation Necrosis (RN)0% reported in peer-reviewed publications3-10

Of the published RN, all have been medically managed3-10		Up to 50%Of the published GammaTile-related RN, all have been medically managed2-9
Maximum dose of radiation (Dmax) to brain tissueMinimal due to eliminating direct contact of the seeds with the adjacent brain tissue and uniform source spacing due to the structural collagen matrixHigh risk due to direct contact of seeds with adjacent brain tissue and uneven seed distributionReduces Dmax to brain tissue with structural offset and uniform seed spacing
Long-term Radiation ExposureReduced due to rapid decay of Cs-131Significant due to prolonged exposure from ~60-day half-lifeEliminates extended exposure with rapid dose delivery
Dosimetry PredictabilityUniform radiation-source spacing helps give predictable, therapeutic radiation doseModerate precision, requires more planningReliable, efficient planning and outcomes with the collagen matrix, and marked reproducibility from patient to patient
Seed MigrationFixed within a bioresorbable collagen matrixHigher risk of migration reported in studiesSignificantly reduces risk of migration with secure tile design
Staff Radiation ExposureMinimal: preloaded tiles minimize handling timeProlonged due to longer implantation times and potentially longer hospital staysTile design limits staff radiation exposure
ApplicationsIdeal for localized CNS tumorsBroader tumor beds, but with more potential side effectsMore precise for localized tumor control
FeatureGammaTile
(with Cs-131)2		Traditional
Brachytherapy
(with Iodine-125)2
Half-life9.7 days 59.4 days
Radiation Dose DeliveryCompletes 88% in 30 days3Completes 88% in 184 days3
Reoperation Related to Radiation Necrosis (RN)0% reported in peer-reviewed publications3-10

Of the published RN, all have been medically managed3-10		Up to 50%
Maximum dose of radiation (Dmax) to brain tissueMinimal due to eliminating direct contact of the seeds with the adjacent brain tissue and uniform source spacing due to the structural collagen matrixHigh risk due to direct contact of seeds with adjacent brain tissue and uneven seed distribution
Long-term Radiation ExposureReduced due to rapid decay of Cs-131Significant due to prolonged exposure from ~60-day half-life
Dosimetry PredictabilityUniform radiation-source spacing helps give predictable, therapeutic radiation doseModerate precision, requires more planning
Seed MigrationFixed within a bioresorbable collagen matrixHigher risk of migration reported in studies
Staff Radiation ExposureMinimal: preloaded tiles minimize handling timeProlonged due to longer implantation times and potentially longer hospital stays
ApplicationsIdeal for localized CNS tumorsBroader tumor beds, but with more potential side effects


FeatureGammaTile
(with Cs-131)2		Benefit of
GammaTile2
Half-life9.7 days Shorter treatment duration, faster radiation delivery
Radiation Dose DeliveryCompletes 88% in 30 days3Faster therapeutic effect
Reoperation Related to Radiation Necrosis (RN)0% reported in peer-reviewed publications3-10

Of the published RN, all have been medically managed3-10		Of the published GammaTile-related RN, all have been medically managed2-9
Maximum dose of radiation (Dmax) to brain tissueMinimal due to eliminating direct contact of the seeds with the adjacent brain tissue and uniform source spacing due to the structural collagen matrixReduces Dmax to brain tissue with structural offset and uniform seed spacing
Long-term Radiation ExposureReduced due to rapid decay of Cs-131Eliminates extended exposure with rapid dose delivery
Dosimetry PredictabilityUniform radiation-source spacing helps give predictable, therapeutic radiation doseReliable, efficient planning and outcomes with the collagen matrix, and marked reproducibility from patient to patient
Seed MigrationFixed within a bioresorbable collagen matrixSignificantly reduces risk of migration with secure tile design
Staff Radiation ExposureMinimal: preloaded tiles minimize handling timeTile design limits staff radiation exposure
ApplicationsIdeal for localized CNS tumorsMore precise for localized tumor control

GammaTile vs. traditional brachytherapy:
the difference is the source: Cs-1312,3

GammaTile doesn’t just treat brain tumors —
it transforms how they are treated.

By combining cutting-edge radiation technology with surgical precision and a patient-focused approach, GammaTile sets a new brachytherapy standard for effectiveness, safety, and efficiency in brain tumor care.2,11

REFERENCE: 1. Kutuk T, et al. Brachytherapy. 23(6):751-760 (2024). 2. Kutuk T, et al. Brachytherapy and Radiation Principles in Clinical Practice. 48:795-820 (2024). 3. Brachman DG, et al. J Neurosurg. 131(6):1819-1828 (2018). 4. Nakaji P, et al. Cureus. 12(11):e11570 (2020). 5. Imber BS, et al. J Neurooncol. 159(3):609-618 (2022). 6. Kutuk T, et al. Brachytherapy. 22(6):872-881 (2023). 7. Dharnipragada R, et al. Neurooncol Adv. 5(1):vdad062 (2023). 8. Gessler DJ, et al. Neurooncol Adv. 4(1):1-11 (2022). 9. Smith N, et al. Neuro Oncol. 24(S6):S4-S15 (2022). 10. Yekula A, et al. J Neurooncol. 166(3):441-450 (2024). 11. Gessler DJ, et al. Future Oncol. 16(30):2445-2455 (2020).
MKT-479-01